IVERMEK

Packaging: Ivermek® is prepackaged in hermetically sealed glass vials (with the capacity of 1, 10, 20, 50, 100, 250 and 500 ml)

ADVANTAGES
- The drug is very effective against diseases caused by nematodes, arachnids and insects and their eggs
- Even small doses of drug have high therapeutic efficiency
- The drug is active for 10-14 days
- The drug is less toxic compared to its analogues
- Intramuscular application ensures fast therapeutic effect

CONTENTS
Active substances – ivermectin (10 mg/ml) and vitamin E (40 mg/ml), auxiliary components

PHARMACOLOGIC PROPERTIES:

Ivermek® is very effective against larva and mature forms of gastrointestinal and pulmonary nematodes as well as larvae of bomb flies, bot flies, stomach bot flies, lice, louse flies and sarcoptoid mites. Ivermectin also increases inhibitory neurotransmitter (γ-aminobutiric acid) production which leads to disruption of nerve impulses, paralysis and subsequent death of parasitic agent. Ivermek® is quickly absorbed from the place of injection and distributed along organs and tissues of animal which helps to prolong drug’s antiparasitic activity for 10-14 days. If the recommended dose is observed, the drug does not have any embrytoxic, teratogenic or mutagenic effect. The drug leaves the body with urine and bile; for lactating animals it can also partially leave the body with milk. The drug quickly decomposes in ambient environment.

PROPOSED CLINICAL USE

Ivermek® can be applied to bovine animals, sheep, goats, horses, deer, camels, dogs and cats as a curative and preventative measure against pulmonary and gastrointestinal helminthosis including dictyocaulosis, metastrongylosis, trichostrongylatosis, strongyloidosis, ascariasis, oesophagostomiasis, ascariasis, oesophagostomiasis, bunostomosis etc; thelaziosis (caused by eye nematodes); hypodermosis, oestrosis (caused by bot flies and bomb flies); psoroptic mange and sarcoptic mange (itches); follicular mange; sifunculatosis (lice infestation) and mallophagosis.

DOSAGE AND METHOD OF APPLICATION

The drug shall be applied to animals in accordance with all aseptic regulations: for pigs, the drug is injected into regions of neck and internal surface of thigh; for other animals, the drug is injected into regions of croup and neck. The injected dose shall be as follows:
- 1.0 ml of Ivermek per 50 kg of animal weight (200 μg of ivermectin per 1 kg) for bovine and small cattle and horses;
- 1.0 ml of Ivermek per 33 kg of animal weight (300 μg of ivermectin per 1 kg) for pigs.
- 0.1 ml of Ivermek per 5 kg of animal weight for cats and dogs.
In severe cases of sarcoptic mange, the drug shall be applied once again after 8-10 days since the first application.
If the required volume of drug exceeds 10.0 cm3, several injections in various places shall be made.
The animals shall be treated against nematode-caused diseases in autumn before transferring to stables and in spring before transferring to pastures; against gadfly invasions – straight after the end of gadfly swarming season; against arachnid- and insect-caused diseases – according to results of veterinary observation.
Before mass application of Ivermek, each drug series is first tested on a small group of animals (7-10 subjects). If no complications are observed after 3 days, the rest of the herd shall be treated with this drug series.
In order to make more precise doses for smaller domestic animals (dogs, cats), Ivermek can be diluted with any sterile solvent. Thus, if animal weighs less than 5 kg, Ivermek shall be diluted by 10 times (in this case, dose will be 0.2 ml per 1 kg of animal weight).

CONTRAINDICATIONS

Ivermek® shall not be applied in the cases as follows: to milch animals; to emaciated animals or animals with infectious diseases; to pregnant animals within 28 days before the start of lactation.
If an individual animal is hypersensitive to ivermectin, it may experience the following symptoms: increased agitation and salivation (for dogs, vomiting); more frequent defecation and urination; ataxia. These symptoms usually disappear by themselves without application of any therapeutic agents.
Be especially careful when applying Ivermek® to the following breeds of dogs: collie, Shetland sheepdogs and Old English Sheepdog.

RESTRICTIONS

12. Treated animals can be slaughtered for food no sooner than 28 days after last injection of Ivermek. In the case of compulsory slaughter occurring before the above stated period, meat of slaughtered animals can be used as fur animal feed.


SHELF LIFE
18 months since the date of production.

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